Publications Univ.-Prof. Dr. rer. nat. Stefanie Scheu

Salmon J.M., I. Todorovski, S.J. Vervoort, K.L. Stanley, C.J. Kearney, L. Martelotto, F. Rossello, T. Semple, G. Mir-Arnau, M. Zethoven, M. Bots, E. Vidacs, K. McArthur, E. Gressier, N.de Weerd, J. Lichte, M.J. Kelly, L. Cluse, S.J. Hogg, P.J. Hertzog, L. Kats, D.D. de Carvalho, S. Scheu, S. Bedoui, B.T. Kile, A. Wei, P.M. Dominguez, and R.W. Johnstone. 2022, Epigenetic reprogramming of plasmacytoid dendritic cells drives type I interferon-dependent differentiation of acute myeloid leukemias for therapeutic benefit. Cancer Discov. 12:1560-1579.

Yang, X., S. Ali, M. Zhao, L. Richter, V. Schäfer, J. Schliehe-Diecks, M. Frank, J. Qi, P.-K. Larsen, J. Skerra, H. Islam, T. Wachtmeister, C. Alter, A. Huang, S. Bhatia, K. Köhrer, C. Kirschning, H. Weighardt, U. Kalinke, R. Kalscheuer, M. Uhrberg, and S. Scheu. 2022, The mycotoxin Beauvericin exhibits immunostimulatory effects on dendritic cells via activating the TLR4 signaling pathway. Front Immunol. 13:856230

 

Dalod, M. and S. Scheu. 2022, Dendritic cell functions in vivo: a user's guide to current and next generation mutant mouse models. Eur J Immunol, published ahead of print, DOI: 10.1002/eji.202149513

Mann-Nüttel, R., S. Ali, P. Petzsch, K. Köhrer, J. Alferink, and S. Scheu. 2021, The transcription factor reservoir and chromatin landscape in activated plasmacytoid dendritic cells. BMC Genom Data. 22:37.

Leite Dantas, R., J. Freff, O. Ambrée, E.C. Beins, A.J. Forstner, U. Dannlowski, B.T. Baune, S. Scheu*, and J. Alferink. 2021, Dendritic Cells: Neglected Modulators of Peripheral Immune Responses and Neuroinflammation in Mood Disorders? Cells. 10:941.

Gaffal E.*, A.M. Kemter*, S. Scheu*, R.L. Dantas, J. Vogt, B. Baune, T. Tüting, A. Zimmer and J. Alferink. 2020, Canabinoid receptor 2 modulates maturation of dendritic cells and their capacity to induce hapten-induced contact hypersensitivity. Int J Mol Sci. 21.

Richter L., S. Kropp, P. Proksch and S. Scheu. 2019, A mouse model-based screening platform for the identification of immune activating compounds such as natural products for novel cancer immunotherapies. Bioorg Med Chem. 27:115145.

Howe M., J. Bauer, A. Schulze, S. Kropp, R.M. Locksley, J. Alferink, H. Weighardt and  S. Scheu. 2019, Production of IFNβ by Conventional Dendritic Cells after Stimulation with Viral Compounds and IFNβ-Independent IFNAR1-Signaling Pathways are Associated with Aggravation of Polymicrobial Sepsis. Int J Mol Sci. 20.

Ambree O., C. Ruland, P. Zwanziger, L. Klotz, B.T. Baune, V. Arolt, *S. Scheu and *J. Alferink. 2019, Social Defeat Modulates T Helper Cell Percentages in Stress Susceptible and Resilient Mice. Int J Mol Sci. 20.

Ali S., R. Mann-Nüttel, A. Schulze, L. Richter, J. Alferink,  and S. Scheu. 2019, Sources of type I interferons in infectious immunity: plasmacytoid dendritic cells not always in the driver’s seat. Front Immunol. 10:778.

Scheu S., S. Ali, R. Mann-Nüttel, L. Richter, V. Arolt, U. Dannlowski, T. Kuhlmann, L. Klotz, and J. Alferink. 2019, Interferon β-Mediated Protective Functions of Microglia in Central Nervous System Autoimmunity. Int J Mol Sci. 20. 

Culmsee, C., S. Michels, S. Scheu, V. Arolt, U. Dannlowski, and J. Alferink. 2018, Mitochondria, Microglia, and the Immune System-How Are They Linked in Affective Disorders?. Front Psychiatry. 9:739.

Pohlmann S., S. Scheu, V. Ziegler, N. Schupp, C. Henninger, and G. Fritz. 2018, Hepatic Rac1 GTPase contributes to liver-mediated basal immune homeostasis and LPS-induced endotoxemia. Biochim Biophys Acta. 1865:1277-1292. 

Ambree O., C. Ruland, S. Scheu, V. Arolt and J. Alferink. 2018, Alterations of the innate immune system in susceptibility and resilience after social defeat stress. Front Behav Neurosci. 12:41.

Ali S., A. Hoven , R.J. Dress, H. Schaal, J. Alferink and S. Scheu. 2018, Identification of a novel Dlg2 isoform differentially expressed in IFNβ-producing plasmacytoid dendritic cells. BMC Genomics. 19:194.

Shinde P., H. Xu, S. Maney, A. Kloetgen, S. Namineni, Y. Zhuang, N. Honke, N. Shaabani, N. Bellora, M. Doerrenberg, M. Trilling, V. Pozdeev, N. van Roojen, S. Scheu, K. Pfeffer, P. Crocker, M. Tanaka, S. Duggimpudi, P. Knolle, M. Heikenwalder, J. Ruland, T. Mak, D. Brenner, A. Pandyra, J. Hoell, A. Borkhardt, D. Häussinger, K. Lang and P. Lang. 2018, TNF-mediated survival of CD169+ cells promotes immune activation during vesicular stomatitis virus infection. J Virol. 92.

Ahmetspahic D., K. Schwarte, O. Ambree, C. Bürger, V. Falcone, K. Seiler, M.R. Kooybaran, L. Grosse, F. Roos, J. Scheffer, S. Jörgens, K. Koelkebeck, U. Dannlowski, V. Arolt, *S. Scheu and *J. Alferink. 2018, Altered B cell homeostasis in patients with major depressive disorder and normalization of regulatory B cell frequencies in treatment responders. J Neuroimmune Pharmacol. 13:90-99.  

Smirnov A., S. Pohlmann, M. Nehring, S. Ali, R. Mann-Nüttel, S. Scheu, A.C. Antoni, W. Hansen, M. Buettner, M.J. Gardiasch, A.M. Westendorf, F. Wirsdörfer, E. Pastille, M. Dudda, and S.B. Flohé. 2017, Sphingosine 1-phosphate- and CCR2-dependent activation of CD4+ plasmacytoid dendritic cells in the bone marrow contributes to signs of sepsis-induced immunosuppression. Front Immunol. 8:1622. 

Scheu S., S. Ali, C. Ruland, V. Arolt, and J. Alferink. 2017, The CC chemokines CCL17 and CCL22 and their receptor CCR4 in CNS autoimmunity. Int J Mol Sci. 18. 

Ruland C., H. Renken, I. Kuzmanov, A. Fattahi Mehr, K. Schwarte, M. Cerina, A. Herrmann, D.M. Otte, A. Zimmer, N. Schwab, S.G. Meuth, V. Arolt, L. Klotz, I. Förster, S. Scheu* and J. Alferink*. 2017, Chemokine CCL17 is expressed by dendritic cells in the CNS during experimental autoimmune encephalomyelitis and promotes pathogenesis of disease. Brain Behav Immun. 66:382-393.

Kalkavan H., P. Sharma, S. Kasper, I. Helfrich, A.A. Pandyra, A. Gassa, I. Virchow, L. Flatz, T. Brandenburg, S. Namineni, M. Heikenwalder, B. Höchst, P.A. Knolle, G. Wollmann, S. von Laer, I. Drexler, J. Rathbun, P. Cannon, S. Scheu, J. Bauer, J. Chauhan, D. Häussinger, G. Willimsky, M. Löhning, D. Schadendorf, S. Brandau, M. Schuler, P.A. Lang and K.S. Lang. 2017, Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumor regression. Nat Commun. 8:1447.

Shaabani, N., N. Honke, V. Duhan, V. Khairnar, A. Gassa, R. Ferrer-Tur, D. Häussinger, M. Becher, G. Zelinskyy,U. Dittmer, S. Scheu, C. Hardt, P. Lang, J. Lu, K. Lang and M. Trilling. 2016, CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection. Cell Death Dis. 7:e2446.

Gross, C.C., D. Ahmetspahic, T. Ruck, A. Schulte-Mecklenbeck, K. Schwarte, S. Jörgens, S. Scheu, S. Windhagen, B. Graefe, N. Melzer, L. Klotz, V. Arolt, H. Wiendl, S.G. Meuth and J. Alferink. 2016, Alemtuzumab-treatment alters circulating innate immune cells in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 3:e289.

Kochs, G., M. Anzaghe, S. Kronhart, V. Wagner, P. Gogesch, S. Scheu, S. Lienenklaus, and Z. Waibler. 2016, In vivo conditions enable IFNAR-independent type I interferon production by peritoneal CD11b+ cells upon Thogoto virus infection. J Virol. 90:9330-7.

Alferink, J., S. Specht, H. Arends, B. Schumak, Ki. Schmidt, C. Ruland, R. Lundt, A. Kemter, A. Dlugos, J.M. Kuepper, K. Poppensieker, M. Findeiß, Ö. Albayram, D.-M. Otte, J. Marazzi, J. Gertsch, I. Förster, W. Maier, S. Scheu, A. Hoerauf, and A. Zimmer. 2016, Cannabinoid receptor 2 modulates susceptibility to experimental cerebral malaria through a CCL17- dependent mechanism. J Biol Chem. 291:19517-31.

Ambrée, O., I. Klassen, I. Förster, V. Arolt, S. Scheu, and J. Alferink. 2016, Reduced locomotor activity and exploratory behavior in CC chemokine receptor 4 deficient mice. Behav Brain Res. 314:87-95.

Bauer, J., R. J. Dress, A. Schulze, P. Dresing, S. Ali, R. Deenen, J. Alferink, and S. Scheu. 2016, Cutting Edge: IFNβ expression in the spleen is restricted to a subpopulation of pDCs exhibiting a specific immune modulatory transcriptome signature. J Immunol. 196:4447-51.

Hochheiser K., M. Klein, C. Gottschalk, F. Hoss, S. Scheu, C. Coch, G. Hartmann, and C. Kurts. 2016, Cutting Edge: The RIG-I Ligand 3pRNA Potently Improves CTL Cross-Priming and Facilitates Antiviral Vaccination. J Immunol. 196:2439-43.

Del Rio M.L., C. Fernandez-Renedo, O. Chalon, S. Scheu, K. Pfeffer, Y. Shintani, J.A. Perez-Simon, P. Schneider, J.I. Rodriguez-Barbosa. 2016, Immunotherapeutic targeting of LIGHT/LTβR/HVEM pathway fully recapitulates the reduced cytotoxic phenotype of LIGHT-deficient T cells. MAbs. 8:478-90.

Kocur M., R. Schneider, A. Pulm, J. Bauer, S. Kropp, M. Gliem, J. Ingwersen, N. Goebels, J. Alferink, T. Prozorovski, O. Aktas, S. Scheu. 2015, IFNβ secreted by microglia mediates clearance of myelin debris in CNS autoimmunity. Acta Neuropathol Commun. 3:20.

Kemter A.M.*, S. Scheu*, N. Hüser, C. Ruland, B. Schumak, M. Findeiß, Z. Cheng, V. Assfalg, V. Arolt, A. Zimmer, J. Alferink. 2015, The cannabinoid receptor 2 is involved in acute rejection of cardiac allografts. Life Sci. 138:29-34.

Petermann P., K. Thier, E. Rahn, F.J. Rixon, W. Bloch, S. Özcelik, C. Krummenacher, M.J. Barron, M.J. Dixon, S. Scheu, K. Pfeffer, D. Knebel-Mörsdorf. 2015, Entry mechanisms of herpes simplex virus 1 into murine epidermis: involvement of nectin-1 and herpesvirus entry mediator as cellular receptors. J Virol. 89:262-74.

Döring M., I. Lessin, T. Frenz, J. Spanier, A. Kessler, P. Tegtmeyer, F. Dag, N. Thiel, M. Trilling, S. Lienenklaus, S. Weiss, S. Scheu, M. Messerle, L. Cicin-Sain, H. Hengel, U. Kalinke. 2014, M27 expressed by cytomegalovirus counteracts effective type I IFN induction of myeloid cells, but not of plsmacytoid dendritic cells. J Virol. 88:13638-50.

Del Rio M.L., C. Fernandez-Renedo, S. Scheu, K. Pfeffer, Y. Shintani, M. Kronenberg, O. Chaloin, P. Schneider, J.I. Rodriguez-Barbosa. 2014, Therapeutic Blockade of LIGHT Interaction With Herpesvirus Entry Mediator and Lymphotoxin  ? Receptor Attenuates In Vivo Cytotoxic Allogeneic Responses. Transplantation. 98:1165-74.

Frenz T., L. Graalmann, C.N. Detje, M. Döring, E. Grabski, S. Scheu, U. Kalinke. 2014, Independent of Plasmacytoid Dendritic Cell (pDC) infection, pDC Triggered by Virus-Infected Cells Mount Enhanced Type I IFN Responses of Different Composition as Opposed to pDC Stimulated with Free Virus. J Immunol. 193:2496-503.

Grusdat M., D.R. McIlwain, H.C. Xu, V.I. Pozdeev, J. Knievel, S.Q. Crome, C. Robert-Tissot, R.J. Dress, A.A. Pandyra, D.E. Speiser, E. Lang, S.K. Maney, A.R. Elford, S.R. Hamilton, S. Scheu, K. Pfeffer, J. Bode, H.-W. Mittrücker, M. Lohoff, M. Huber, D. Häussinger, P.S. Ohashi, T.W. Mak, K.S. Lang, P.A. Lang. 2014, IRF4 and BATF are critical for CD8+ T-cell function following infection with LCMV. Cell Death Differ. 21:1050-30.

Rönsberg D., A. Debbab, A. Mándi, V. Vasylyeva, P. Böhler, B. Stork, L. Engelke, A. Hamacher, R. Sawadogo, M. Diederich, V. Wray, W. Lin, M.U. Kassack, C. Janiak, S. Scheu, S. Wesselborg, T. Kurtán, A.H. Aly, P. Proksch. 2013, Pro-apoptotic and immunostimulatory tetrahydroxanthone dimers from the endophytic fungus Phomopsis longicolla. J Org Chem. 78:12409-25.

Mana P., D. Linares, D.G. Silva, S. Fordham, S. Scheu, K. Pfeffer, M. Staykova, M.E. Bertram. 2013, LIGHT (TNFSF14/CD258) Is a Decisive Factor for Recovery from Experimental Autoimmune Encephalomyelitis. J Immunol. 191:154-63.

Lang P.A., N. Shaabani, S. Borkens, N. Honke, S. Scheu, S. Booth, D. Brenner, A. Meryk, C. Barthuber, M. Recher, T.W. Mak, P.S. Ohashi, D. Häussinger, G.M. Griffiths, A.J. Thrasher, G. Bouma, K.S. Lang. 2013, Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency. J Allergy Clin Immunol. 131:815-824.

Poppensieker K., D.M. Otte, B. Schürmann, A. Limmer, P. Dresing, E. Drews, B. Schumak, L. Klotz, J. Raasch, A. Mildner, A. Waisman, S. Scheu, P. Knolle, I. Förster, M. Prinz, W. Maier, A. Zimmer, J. Alferink. 2012, CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells. Proc Natl Acad Sci U S A. 109:3897-902.

Zhao M., J. Zhang, H. Phatnani, S. Scheu, T. Maniatis. 2012, Stochastic Expression of the Interferon-β Gene. PLoS Biol. 10:e1001249.

Stanley A.C., F. de Labastida Rivera, A. Haque, M. Sheel, Y. Zhou, F.H. Amante, P.T. Bunn, L.M. Randall, K. Pfeffer, S. Scheu, M.J. Hickey, B.M. Saunders, C. Ware, G.R. Hill, K. Tamada, P.M. Kaye, C.R. Engwerda. 2011, Critical roles for LIGHT and its receptors in generating T cell-mediated immunity during leishmania donovani infection. PLoS Pathog. 7:e1002279.

Doherty T.A., P. Soroosh, N. Khorram, S. Fukuyama, P. Rosenthal, J.Y. Cho, P.S. Norris, H. Choi, S. Scheu, K. Pfeffer, B.L. Zuraw, C.F. Ware, D.H. Broide, M. Croft. 2011, The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling. Nat. Med. 17:596-603.

Soroosh, P., T.A. Doherty, T. So, A.K. Mehta, N. Khorram, P.S. Norris, S. Scheu, K. Pfeffer, C. Ware, M. Croft. 2011, Herpesvirus entry mediator (TNFRSF14) regulates the persistence of T helper memory cell populations. J. Exp. Med. 208:797-809.

Dresing, P., S. Borkens, M. Kocur, S. Kropp, S. Scheu. 2010, A fluorescence reporter model defines "TipDCs" as the cellular source of interferon beta in murine Listeriosis. PLoS One 5:e15567.

Messler, S., S. Kropp, V. Episkopou, A. Felici, J. Würthner, R. Lemke, M. Jerabek-Willemsen, R. Willecke, S. Scheu, K. Pfeffer, J.U. Wurthner. 2010, The TGF-β signaling modulators TRAP1/TGFBRAP1 and VPS39/Vam6/TLP are essential for early embryonic development. Immunobiology 216:343-50.

Lang, P.A., M. Recher, N. Honke, S. Scheu, S. Borkens, N. Gailus, C. Krings, A. Meryk, A. Kuwalik, L. Cervantes-Barragan, N. van Rooijen, U. Kalinke, B. Ludewig, H. Hengartner, N. Harris, D. Häussinger, P.S. Ohashi, R.M. Zinkernagel, and K.S. Lang. 2010, Tissue macrophages suppress viral replication and prevent severe immunopathology in an Interferon-I-dependent manner in mice. Hepatology 52:25-32.

Beer-Hammer, S., E. Zebedin, M. von Holleben, J. Alferink, B. Reis, P. Dresing, D. Degrandi, S. Scheu, E. Hirsch, V. Sexl, K. Pfeffer, and B. Nürnberg, R.P. Piekorz. 2010, The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation. J. Leukc. Biol. 87:1083-95.

Scheu, S., P. Dresing, and R.M. Locksley. 2008, Visualization of IFN beta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo. Proc. Natl. Acad. Sci. U. S. A. 105:20416-21.

Randall, L.M., F.H. Amante, Y. Zhou, A.C. Stanley, A. Haque, F. Rivera, K. Pfeffer, S. Scheu, G.R. Hill, K. Tamada, and C.R. Engwerda. 2008, Cutting edge: Selective blockade of LIGHT-lymphotoxin beta receptor signaling protects mice from experimental cerebral malaria caused by Plasmodium berghei ANKA. J. Immunol. 181:7458-62.

Cisse B., M.L. Caton, M. Lehner, T. Maeda, S. Scheu, R. Locksley, D. Holmberg, C. Zweier, N.S. den Hollander, S.G. Kant, W. Holter, A. Rauch, Y. Zhuang, and B. Reizis. 2008, Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell. 135:37-48.

Togbe, D., P. Loureiro de Sousa, M. Fauconnier, V. Boissay, L. Fick, S. Scheu, K. Pfeffer, R. Menard, G.E. Grau, B.T. Doan, J.C. Beloeil, L. Renia, A. Hansen, H. Ball, N. Hunt, B. Ryffel, and V.F.J. Quesniaux. 2008, Both functional LT beta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. PLoS ONE 3:e2608.

Summers-DeLuca, L. E., D.D. McCarthy, B. Cosovic, L.A. Ward, C.C. Lo, S. Scheu, K. Pfeffer, and J.L. Gommerman. 2007, Expression of lymphotoxin-alphabeta on antigen-specific T cells is required for DC function. J. Exp. Med. 204:1071-1081.

Scheu, S., D.B. Stetson, R.L. Reinhardt, J.H. Leber, M. Mohrs, and R.M. Locksley. 2006, Activation of the integrated stress response during T helper cell differentiation. Nat. Immunol. 7:644-51.

Banks T.A., S. Rickert, C.A. Benedict, L. Ma, M. Ko, J. Meier, W. Ha, K. Schneider, S.W. Granger, O. Turovskaya, D. Elewaut, D. Otero, A.R. French, S.C. Henry, J.D. Hamilton, S. Scheu, K. Pfeffer, and C.F. Ware. 2005, A lymphotoxin-interferon beta axis essential for lymphocyte survival revealed during cytomegalovirus infection. J. Immunol. 174: 7217-7225.

Sedy, J.R., M. Gavrieli, K.G. Potter, M.A. Hurchla, R.C. Lindsley, K. Hildner, S. Scheu, K. Pfeffer, C.F. Ware, T.L. Murphy, and K.M. Murphy. 2004, B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat. Immunol. 6:90-8.

Stetson D.B., D. Voehringer, J.L. Grogan, M. Xu, R.L. Reinhardt, S. Scheu, B.L. Kelly, and R.M. Locksley. 2004, Th2 cells: orchestrating barrier immunity. Adv. Immunol. 83:163-89. Review

Boehm, T., S. Scheu, K. Pfeffer, and C.C. Bleul. 2003, Thymic medullary epithelial cell differentiation, thymocyte emigration and the control of autoimmunity require lympho-epithelial crosstalk via LTbR. J. Exp. Med. 198:757-769.

Ehlers, S., C. Holscher, S. Scheu, C. Tertilt, T. Hehlgans, J. Suwinski, R. Endres, and K. Pfeffer. 2003, The Lymphotoxin beta Receptor Is Critically Involved in Controlling Infections with the Intracellular Pathogens Mycobacterium tuberculosis and Listeria monocytogenes. J. Immunol. 170: 5210-5218.

Scheu, S., J. Alferink, T. Potzel, W. Barchet, U. Kalinke, and K. Pfeffer. 2002, Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin b in mesenteric lymph node genesis. J. Exp. Med. 195: 1613-1624.